In 1997 Derbez made his directing debut in a soap opera named No Tengo Madre. In 1999 Derbez started a comedy show, Derbez en Cuando. Derbez appeared in Carita de Angel in 2000. He also starred that year in Cómplices al Rescate ("Accomplices to the Rescue"). In 2003 he produced a television series named XHDRBZ. He later produced Hospital el Paisa ("Countrymen Hospital"), Vecinos ("Neighbors"), and in 2009 Ellas son. . . la alegría del hogar. He was the leading man in La familia P. Luche'.